Genetically engineered production of 1-desmethylcobyrinic acid, 1- desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in E. coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin*

Genetically engineered production of 1-desmethylcobyrinic acid, 1desmethylcobyrinic acid a,c-diamide, and cobyrinic acid a,c-diamide in E. coli implies a role for CbiD in C-1 methylation in the anaerobic pathway to cobalamin* Charles A. Roessner, Howard J. Williams, and A. Ian Scott Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255 Running Title: The Role of CbiD in Cobalamin Synthesis Address correspondence to: Charles A. Roessner, Department of Chemistry, Texas A&M University, College Station, Texas 77843-3255. Tel. 979 845-8985; Fax. 979 845-5992; E-Mail: [email protected]